Carebox connects patients, families, and their physicians with treatment options only available in clinical trials. Its clinical trial matching technology uses PhD-supervised artificial intelligence and automation to continuously index clinical trial participation eligibility criteria for instantaneous matching of patients' clinical and genomic profiles with all relevant studies. Carebox Connect solutions built with this technology have already been visited by over 1 million patients and physicians. Pharmaceutical trial sponsors, hospital research centers, and patient advocacy groups use Carebox Connect for patient-centric navigation, education, matching, and referral to present their clinical trial portfolios to the public, optimize trial recruitment, and enhance participant diversity in support of ongoing clinical research. For patients, their families, and treating physicians, Carebox Connect is a much-enhanced version of ClinicalTrials.gov optimized to connect them with treatment options.