Conflu3nce applies its patented methods to the early detection of cognitive health changes in people across the cognitive spectrum. The company is developing PICSSi, a minimally-disruptive, on-demand system that addresses cognitive-motor issues for people across a wide range of ages and conditions, including Alzheimers disease, traumatic brain injury, Parkinsons disease, stroke, and attention-deficit/hyperactivity disorder. The systems multi-modal, multi-domain-based personalized interactive units are designed to cooperatively engage global cognition and can be delivered as hands-on or virtual/view-only experiences. The company's PICSSi and Stitch and Peel (SnP) technology is based on processes and methods that use content-rich, dynamic, 3D-like figure-ground image sets with image properties that can be manipulated and predicted. For early detection, PICSSi can be personalized to capture an individuals cognitive expression pattern without bias toward disease/symptom trajectories or domain-specific deficits. User-specific baselines are used to detect changes in cognition over time. And for training/remediation, users are guided through increasingly challenging interactions to develop and retrain their skills, processes, and processing based on their dynamic progress.