PillTracker is an adherence system that helps patients and doctors collaboratively manage medication consumption. Leveraging a patented conductive layer, advanced Qualcomm chipset, and a familiar Android-based user interface, PillTracker streamlines adherence throughout the lifecycle of the medication for the patient and doctor alike. PillTracker approaches medication adherence from both directions, reminding the patient about their prescribed dose, while tracking their medication use in near-real time on behalf of the healthcare provider. All of this is made possible by smart blister packaging paired with a user-friendly medication dispenser. PillTracker enables precise and efficient clinical trials by tracking medication use in near-real time, accepting patient feedback, and offering direct engagement between study staff and participants. PillTracker extends electronic clinical trial management systems into the hands of the patient. Additionally, study staff can update prescribed dosing for patients, send them notifications, and accept formal case report forms through the device.