PolyHeal is an advanced medical device company that utilizes its microsphere-based wound-care technology to develop active wound-healing products for chronic skin ulcers, burns, trauma, and post-surgery wounds. PolyHeals patented wound-management technology uses chemically inert, non-biodegradable, charged synthetic microspheres to initiate and promote the wound-healing process, without the addition of any pharmacologically active agents. PolyHeal is approved as a CE marked class IIb medical device in the European Union, Russia, and Israel. The company has signed a cooperation agreement with Spanish company Praxis, which specializes in marketing orphan drugs. PolyHeal was acquired by Mediwound in 2010, and in 2015 Clal Biotechnology Industries Ltd owned a 47% stake in PolyHeal.