PregnanTech is developing the Lioness, a small, disposable device designed to maintain the natural resistance of the cervix in order to prevent preterm birth. The Lioness is positioned around the uterine cervix and behaves like a shock absorber, allowing transient shortening and dilation of the cervix during contractions and then restoring the cervix to its initial state when contractions subside. The device is inserted by a physician during an outpatient visit and removed at term. PregnanTech has conducted a range of successful preclinical studies and in 2019 began a clinical safety study of Lioness among non-pregnant women intended for hysterectomy. Initial findings demonstrate the significant potential inherent in the device. Professor Kypros Nicolaides, a preeminent obstetrician from Kings College Hospital in London, has expressed his interest in leading a first clinical trial in 2021 among pregnant women at risk of preterm birth. PregnanTech is part of the Trendlines Group.