Silexion Therapeutics
Formerly Silenseed
Development of Innovative Treatments for Pancreatic Cancer
Startup Public Health Tech & Life Sciences Est. 2008
Total Raised
$27.65M
Public
Last Round
$6M
6 rounds
Investors
1
1 public
Team
1
11-50 employees
Confidence
97/100
News
51
articles
Patents
1
About
Silexion Therapeutics is a pioneering developmental stage company dedicated to the development of innovative treatments for pancreatic cancer. The company conducted phase 2 clinical trial with its first generation product which has shown positive efficacy results vs the control of chemotherapy alone. Silexion’s commitment to pushing the boundaries of therapeutic advancements in the field of oncology, is focused in enhancing its first-generation product (LODERTM) to develop a new formulated product which will improve the clinical efficacy that Silexion observed with its first-generation product against pancreatic cancer. With a strong foundation in RNA interference technology, Silexion Therapeutics develops innovative RNA-based therapeutics designed to silence specific genes involved in pancreatic cancer growth and metastasis. By selectively suppressing these genes, it aims to disrupt tumor progression and enhance the therapeutic response.
Classification
Sector
Health Tech & Life SciencesPharma & Medical BiotechnologyDrugs Discovery & Development
Core Technology
BiologicalsGenes
Target Customer
Healthcare & Life SciencesLife SciencesPharmaceuticals
Business Model
B2B
Tags
drug-discoverybiological-therapycanceroncologydrug-deliverypharmaceuticalscancer-therapy
Funding & Events
Sep 2025
Exit Undisclosed
Sep 2009
Non-equity $6M
Oct 2015
Undisclosed Round $2.35M
Esperante Ventures (Lead)
Jan 2025
PIPE $3.3M
Aug 2024
Exit Undisclosed
Apr 2014
Seed $10M
Esperante Ventures
News (51)
Sep 30, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces Positive New Human Cell Line Data Confirming Pan-KRAS Activity of SIL204, Demonstrating Up to 99.7% Inhibition and First Evidence in Gastric Cancer
Product Stage
Sep 25, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Regains Compliance with Nasdaq Listing Requirements
Product StagePublic Trading
Sep 11, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces Pricing of $6.0 Million Public Offering
PIPE/PO
Sep 11, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Reports Positive Preclinical Data Demonstrating SIL204’s Reach and Activity in Major Pancreatic Cancer Metastatic Sites Following Systemic Administration
Product Stage
Sep 4, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces Selection of Contract Research Organization to Support Upcoming Phase 2/3 Clinical Trials for SIL204
Product StagePartners
Sep 2, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics to Present at the Upcoming 27th Annual H.C. Wainwright Global Investment Conference
Product StageManagement Changes
Aug 12, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Reports Second Quarter 2025 Financial Results and Provides Business Update
Product StagePartners
Aug 1, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces Exercise of Warrants for $1.8 Million Gross Proceeds
PIPE/PO
Jul 31, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces New Preclinical Data Showing Up to 97% Inhibition of Cancer Cell Growth, Including New Evidence Against New Previously Untested KRAS Mutation
Product Stage
Jul 16, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces 1-for-15 Reverse Share Split
Public Trading
Jul 9, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces Positive Results in Preclinical Study Demonstrating Significant SIL204 Efficacy in Human Lung Cancer Cell Lines
Product Stage
May 30, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics announces preclinical results on SIL204
Product StagePartners
May 29, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces Groundbreaking Preclinical Results: SIL204 Shows Strong Efficacy in Pancreatic, Colorectal, and Lung Cancers
Product Stage
May 21, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Completes Key Preclinical Studies Exploring SIL204’s Potential Impact on Colorectal and Lung Cancer
Product Stage
May 13, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Reports First Quarter 2025 Financial Results and Provides Business Update
Product StageInvestmentPIPE/POPartners
Apr 23, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces Collaboration with Global Therapeutics Leader Catalent on Advanced siRNA Formulation Development & Clinical Manufacturing Activities
Product StagePartners
Mar 28, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Unveils Innovative Expanded Development Plan for SIL204 Based on Recent Groundbreaking Preclinical Data
Product Stage
Mar 21, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Announces Completion of Innovative Expanded Development Plan for SIL204 which will be unveiled at the 2025 NeauxCancer Conference
Product Stage
Mar 20, 2025 · www.globenewswire.com
growth-positive
Silexion Therapeutics Announces Completion of Innovative Expanded Development Plan for SIL204 which will be unveiled at the 2025 NeauxCancer Conference
Product Stage
Mar 18, 2025 · finance.yahoo.com
growth-positive
Silexion Therapeutics Reports Full Year 2024 Financial Results and Provides Business Update
Public TradingInvestmentManagement ChangesProduct Stage
+ 31 more articles
Details
Product Stage
Clinical Trial
Employees
11-50
Exact Count
31
District
Center District
Founded
2008
Registrar
514207778
Crunchbase
silenseed
Locations
HaMa'ayan Street 2, Modi'in-Maccabim-Re'ut, Israel
Links
Website
Admin
Last Update
Oct 24, 2025
Verified by
Yanina Wainscheinker
Claimed
Yes
Missing
markets, external profiles
Team (1)
Amotz Shemi, PhD
Co-Founder & CEO
Founder
Internal
Created by
Rebecca Mack (rebeccamack26@gmail.com)
Created
2014-07-29T00:00:00.000Z
Last editor
Yanina Wainscheinker (yanina.wainscheinker@sncentral.org)
Status
Public on NASDAQ on Aug, 2024;