KAHR Medical News
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/PRNewswire/ -- KAHR, a clinical-stage biotech company developing DSP107, a first-in-class bi-specific 4-1BB T-cell engager that activates innate and adaptive...
KAHR, a clinical-stage biotech company, announced positive results from the Phase 2 dose expansion cohort of DSP107 in combination with atezolizumab for treating 3rd line microsatellite stable metastatic colorectal cancer (MSS-CRC). The combination therapy has shown anti-tumor activity and extended survival, including in patients with liver metastases. These results will be presented at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting. DSP107 is a bi-specific 4-1BB T-cell engager that activates both innate and adaptive immunity, targeting CD47 overexpression on cancer cells. This approach is particularly relevant for MSS-CRC, a challenging subtype of colorectal cancer. KAHRs development of DSP107 aims to address the unmet medical need in treating MSS-CRC.
Product StageFDA approved/pending approval
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KAHR Reports Dose Escalation Results from Phase I Trial of DSP107 in Combination with anti-PD-L1 in Patients with Advanced Solid Tumors
KAHR, a clinical-stage biotech company, announced positive results from a Phase I study of its novel immunotherapy, DSP107, in combination with atezolizumab. The study, which focused on patients with advanced solid tumors, demonstrated significant tumor shrinkage and durable responses, particularly in patients with microsatellite stable colorectal cancer (MSS-CRC). The highest dose of DSP107 was selected for Phase II expansion cohorts, showing a disease control rate of 57%. The treatment was well tolerated with no dose-limiting toxicities. These promising results will be presented at the ASCO 2023 Annual Meeting. KAHRs DSP107 targets CD47 and 4-1BB, activating both innate and adaptive immunity to treat solid tumors and blood cancers.
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MIF invests in KAHR to explore lead immunotherapy drug for multiple myeloma
KAHR Medical has received an investment from the Myeloma Investment Fund (MIF) to explore the potential of its leading immunotherapy drug candidate, DSP107, for the treatment of multiple myeloma. The investment reinforces KAHRs commitment to developing innovative treatment approaches for myeloma patients. With this investment, KAHR Medical has raised a total of $59 million since June 2021. DSP107 is a dual-targeting fusion protein that activates innate and adaptive immunity to bolster anti-tumor immunity. It has demonstrated a good safety profile and high disease control rates in a phase 1 trial. MIF is a venture philanthropy fund that invests in promising companies and technologies in oncology to drive the development of new therapies for multiple myeloma.
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KAHR and Cancer Focus Fund Announce First Patient Dosed in Phase 1b Clinical Trial of Anti-CD47 Product Candidate DSP107 in Blood Cancers
KAHR and Cancer Focus Fund have announced the dosing of the first patient in a Phase 1b clinical trial of DSP107, a CD47x41BB targeting fusion protein, in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The trial is being funded by an investment from Cancer Focus Fund. KAHRs CEO, Yaron Pereg, expressed gratitude for the support and highlighted the potential of DSP107 to achieve significant anti-tumor effects across cancer types. The trial is being conducted at MD Anderson and led by Naval Daver. DSP107 is also being tested in a Phase 1/2 clinical trial for solid tumor cancers. KAHR develops novel dual-targeting fusion protein therapeutics that activate both the innate and adaptive immune systems.
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KAHR Announces $46.5 Million Financing to Advance its Multifunctional Immunotherapeutic Pipeline
Cancer immunotherapy company KAHR has announced the first closing of an investment round, raising $46.5 million. The financing, led by aMoon, will be used to advance the clinical development of the companys lead product candidate, DSP107, a CD47x41BB targeting fusion protein for the treatment of solid and blood cancers. The funding will also support the development of KAHRs preclinical pipeline. The successful financing round includes participation from new and existing investors. KAHRs unique approach to cancer immunotherapy aims to unmask cancer cells for immune recognition and trigger a targeted activation of anticancer immunity. The companys lead product candidate, DSP107, is currently being tested in Phase 1/2 studies. KAHRs technology platform utilizes multi-functional immuno-recruitment proteins to selectively target and bind to tumors.
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Samsung Biologics and KAHR Medical Announce Development and Manufacturing Agreement for Cancer Immunotherapy Drug Candidate
Samsung Biologics has signed a strategic partnership with KAHR Medical to provide its development and manufacturing services for KAHRs drug candidate DSP502, a TIGITxPD1 fusion protein. The partnership aims to bring cutting-edge immuno-recruitment cancer drugs to patients in need. KAHR is an innovative leader in the fusion protein space, developing multi-functional immuno-recruitment proteins that selectively target tumors. Samsung Biologics, a leading contract development and manufacturing organization, offers integrated and high-quality development services. The partnership will leverage Samsung Biologics expertise to ensure the success of KAHRs drug candidate.
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KAHR Receives Investment from Cancer Focus Fund to Support Phase 1/2 Study of KAHR's Lead Anti-CD47 Candidate in Blood Cancers
KAHR and Cancer Focus Fund announced that Cancer Focus Fund is investing $5 million to finance a clinical trial of KAHRs lead anti-CD47 candidate, DSP107, in blood cancers. The investment will support a Phase 1/2 clinical study assessing KAHRs CD47x41BB targeting agent in the treatment of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and T-cell lymphoproliferative diseases. The study will be conducted at MD Anderson. DSP107 is a first-in-class CD47x41BB targeting compound that simultaneously targets cancer cells and activates an effective immune response. KAHR is a clinical-stage cancer immunotherapy company developing novel bi-functional fusion proteins.
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KAHR Announces Exclusive Licensing Agreement with Thomas Jefferson University for Novel Platform of Bi- and Tri-Specific Fusion Proteins for Cancer Immunotherapy
KAHR has entered into a licensing agreement with Thomas Jefferson University to develop and commercialize multiple new drug candidates for immuno-oncology. The agreement adds a second fusion protein platform to KAHRs portfolio, positioning the company as a world leader in the fusion protein space. The licensed drug candidates focus on promising checkpoint pathways and target ligands instead of receptors, increasing tumor selectivity. The collaboration with Thomas Jefferson University allows for the expansion of the platform into novel targets and the activation of other immune cell types. KAHRs current technology is based on multi-functional immuno-recruitment proteins that selectively target cancer cells. The companys lead asset, DSP107, is currently being evaluated in a Phase 1/2 study. KAHRs investors include Flerie Invest AB, Oriella Limited, Hadassit Bio Holdings, Pavilion Capital, Mirae Asset, Korean Investment Partners, and DSC Investments.
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https://www.jpost.com/health-science/jerusalem-based-firm-starts-clinical-trials-for-cancer-treatment-648952
Cancer immunotherapy company KAHR has announced the dosing of its first patient in the Phase 1/2 clinical trial for its treatment of solid tumors. The drug, known as DSP107, works by simultaneously targeting cancer cells, weakening their defense mechanisms, and activating the bodys innate and adaptive immune systems to work against the cells. The study will be conducted at multiple leading sites in the United States in collaboration with Roche.
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KAHR Announces Addition of Prof. Hagop M. Kantarjian to Its Clinical Advisory Board
Prof. Hagop M. Kantarjian, a world leader in leukemia treatment, has joined KAHRs clinical advisory board. KAHR is a cancer immunotherapy company developing novel multifunctional immuno-recruitment proteins. Prof. Kantarjians expertise will contribute to the advancement of KAHRs CD47x41BB targeting compound for the treatment of hematological malignancies. KAHRs clinical advisory board also includes other renowned experts in the field. The companys technology platform is based on multi-functional immuno-recruitment proteins that selectively target and bind to tumors, activating both innate and adaptive immunity. KAHR has received investments from Flerie Invest AB, Oriella Limited, Hadassit Bio-Holdings, Pavilion Capital, Mirae Asset, Korean Investment Partners, and DSC Investments.
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KAHR Medical gets FDA nod to start human trials for cancer drug
Israeli biopharmaceutical company KAHR Medical has received FDA clearance to start clinical trials on its immunotherapy drug, DSP-107, to battle cancer. The drug targets cancer cells, weakens their defenses, and activates a local response. KAHR plans to conduct a Phase I/II clinical trial to evaluate the drugs safety and effectiveness. The trial will test DSP-107 as a stand-alone treatment and in combination with another immunotherapy medication developed by Roche. KAHR has raised $18 million to date from various investors.
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Cancer Treatment Company KAHR Medical Raises $18 Million
Jerusalem-based biopharma company KAHR Medical Ltd. has raised $18 million in funding. The company plans to use the funding to advance its immuno-oncology drug candidates, particularly its lead product, DSP107, which targets CD47 and is being tested for the treatment of solid tumors.
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KAHR Medical Announces Clinical Trial Collaboration to Evaluate DSP107 in Combination With a PD-L1 Checkpoint Inhibitor in Advanced Lung Cancer Patients BioSpace
KAHR Medical has announced a new clinical collaboration with Roche to explore the potential of combining KAHRs lead program, DSP107, with Roches checkpoint inhibitor atezolizumab in treating advanced NSCLC patients. The collaboration aims to evaluate the safety, efficacy, and pharmacokinetics of DSP107 as a monotherapy and in combination with atezolizumab. DSP107 is a bi-functional, immunotherapeutic fusion protein that targets CD47-overexpressing tumors and stimulates immune activation. The Phase I/II trial is expected to begin in H1 2020. KAHR Medical is optimistic about the potential of this collaboration to provide treatment options for NSCLC patients with limited options.
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Canada-Israel sign business deals worth $87 million
Ontario Premier Kathleen Wynne signed 18 agreements and partnerships valued at $87 million during a trade mission to Israel. The focus of the visit was on the life sciences and research sectors. Ontario business leaders are seeking Israeli innovation ideas and offering tax breaks in return. Two-way trade between Ontario and Israel last year was valued at over $900 million. The agreements include collaborations in various fields such as healthcare, technology, and education.
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Israeli cancer treatment co KAHR Medical raises $12m
KAHR Medical Ltd has raised $12 million in a Series B financing round, with a total financing round of $15 million. The funding will be used to fund the clinical development of KAHRs lead product, KAHR-102, and the pre-clinical development of KAHR-101 and new pipeline programs. The investors in the financing round include Korea Investment Partners, Mirae Asset Venture Investment, DSC Investment, and Flerie Invest AB. The CEO of KAHR Medical, Dr. Noam Shani, stated that the funding will allow the company to advance their lead products through pre-clinical and clinical development stages.
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